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The arrow in H indicates increased central atrophy on follow-up. G and H, Coronal T1-weighted images show progression of central and parietal atrophy from baseline (G) to follow-up (H). Note that the cortical signal abnormality progresses in contiguous cortical areas. The arrowheads in F indicate increased right superior parietal signal abnormality.

E and F, Bifrontal and biparietal cortical signal abnormality (E) progresses to increased right superior parietal cortical signal abnormality at follow-up (F).

C and D, Signal intensity 0 in the right putamen at baseline (C) progresses to signal intensity 2 (arrowheads) and new right lateral occipital cortical signal abnormality at follow-up (arrow) (D).

A and B, The left temporo-occipital cortical signal abnormality (A) progresses to bilateral temporo-occipital cortical signal abnormality at follow-up 30 months later (arrowhead) (B). A-H, Shown are axial diffusion-weighted images in a 66-year-old woman with the codon 129 methionine valine polymorphism.

Separation studio free serial number .03